| 单词 |
erbB-1 Genes |
| 释义 |
erbB-1 Genes | 《英文msh词典》erbB-1 Genes | | [同义词] erbB-1 Genes | | [主题词] Genes,erbB-1 | | [中文释义] erbB-1基因 | | [英文释义] The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors,commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12. |
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