| 单词 |
G-Protein,Inhibitory Gt |
| 释义 |
G-Protein,Inhibitory Gt | 《英文msh词典》G-Protein,Inhibitory Gt | | [同义词] G-Protein,Inhibitory Gt | | [主题词] Transducin | | [中文释义] G蛋白质,抑制剂Gt | | [英文释义] A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. EC 3.6.1.-. |
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