| 释义 |
Multidrug Resistance Gene 1 | 《英文msh词典》Multidrug Resistance Gene 1 | | [入口词] Multidrug Resistance Gene 1 | | [主题词] Genes,MDR | | [英文释义] Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1 (MDR1) gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41) |
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