| 单词 |
Non-Steroidal Antirheumatic Agents |
| 释义 |
Non-Steroidal Antirheumatic Agents | 《英文msh词典》Non-Steroidal Antirheumatic Agents | | [入口词] Non-Steroidal Antirheumatic Agents | | [主题词] Anti-Inflammatory Agents,Non-Steroidal | | [英文释义] Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions,they have analgesic,antipyretic,and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase,which converts arachidonic acid to cyclic endoperoxides,precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic,antipyretic,and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or phospholipase C or may modulate T-cell function. (AMA Drug Evaluations Annual,1994,p 1814-5) |
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